Focal Segmental Glomerulosclerosis - Treatment

Treatment

  • Salt restriction and diuretics, such as furosemide, for edema
  • Antihypertensives (especially ACEIs) – if the blood pressure is too high
  • treat present hyperlipidemia (e.g. statins, fibrates; although fibrates are contraindicated in renal failure)
  • Aldosterone antagonist to decrease proteinuria and thus offer a degree of reno-protection
  • Angiotensin II receptor antagonist
  • ACE inhibitor
  • Corticosteroids, such as prednisone – based on the clinical judgment of physician (no broad consensus/guideline)
  • Cytotoxics, such as cyclophosphamide may be used to induce remission in patients presenting with FSGS refractory to corticosteroids, or in patients who do not tolerate steroids.
  • Plasmapheresis – blood cleansing using a machine to remove the patient's blood plasma and replacing it with donor plasma.
  • Vitamin E
  • Fish oil
  • Immunosuppressive drugs
  • None – sometimes none of the above works and the patient will require dialysis with possibly later transplantation of a new kidney.

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