FME may refer to:
- Fairbanks Morse Engine, a subsidiary of EnPro Industries, based in Beloit, Wisconsin, that manufactures and services engines
- Feature Manipulation Engine, an integrated collection of tools for spatial data transformation and data translation
- Federación Mexicana de Esgrima, the ruling body of fencing in Mexico
- Financial Supervisory Authority (Iceland) (Icelandic: Fjármálaeftirlitið (FME)), the single supervisory authority for the financial sector in Iceland
- Finnish Metal Expo, a heavy metal expo held annually in Finland
- FME connector, a miniature 50Ω RF connector series
- Force Medical Examiner, police Doctors in the UK
- Forest Movement Europe, a grouping of more than 45 NGOs from 12 European countries working on forest issues
- Formal Methods Europe, an organization proomoting the research and application of formal methods for the improvement of software and hardware in computer-based systems
- Fourier–Motzkin elimination (FME method), a mathematical algorithm for eliminating variables from a system of linear inequalities
- Free-market environmentalism, a position that argues that the free market, property rights, and tort law provide the best tools to preserve the health and sustainability of the environment
- Fujitsu Microelectronics Europe GmbH, former name of Fujitsu Semiconductor Europe GmbH
- Tipton Airport, Anne Arundel County, Maryland, FAA LID code
- Free Music Ensemble (FME), one of the bands featuring Norwegian jazz drummer Paal Nilssen-Love