Mechanism of Action
Fluoxetine's mechanism of action is predominantly that of a serotonin reuptake inhibitor. However, it may also produce some of its effects via its potent 5-HT2C receptor antagonist effects. In addition, fluoxetine has been found to act as an agonist of the σ1-receptor, with a potency greater than that of citalopram but less than that of fluvoxamine, though the significance of this property is not fully clear either.
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