| Gene Ontology | |
|---|---|
| Molecular function | • peptidyl-prolyl cis-trans isomerase activity • receptor binding • ryanodine-sensitive calcium-release channel activity • protein binding • FK506 binding • ion channel binding |
| Cellular component | • cytosol • sarcoplasmic reticulum membrane • calcium channel complex |
| Biological process | • protein peptidyl-prolyl isomerization • 'de novo' protein folding • muscle contraction • smooth muscle contraction • response to glucose stimulus • negative regulation of heart rate • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • peptidyl-proline modification • neuronal action potential propagation • protein maturation by protein folding • insulin secretion • negative regulation of protein phosphatase type 2B activity • protein refolding • T cell proliferation • response to redox state • regulation of ryanodine-sensitive calcium-release channel activity • regulation of voltage-gated calcium channel activity |
| Sources: Amigo / QuickGO | |
24.27 – 24.29 Mb
4.83 – 4.84 Mb
Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.