Mechanism of Action
Unlike other psychostimulants which are dopaminergic, pemoline is thought to be dopamimetic in nature. Pemoline passes the blood brain barrier and acts as a surrogate for dopamine, not affecting endogenous intracellular dopamine. For this reason, and the fact that it has little or no affinity for adrenaline receptors, pemoline has minimal sympathomimetic side effects such as: dry mouth, reduction in appetite, high blood pressure, increased heart rate, constriction of smooth muscle, cardiac stress, dilated pupils and insomnia. There is some data to suggest that pemoline is a nootropic acting as a catalyst conductor in the synapses of the brain's memory centers, raising the efficiency of memory and assisting RNA formation in the brain. While drugs like dexamphetamine and methylphenidate are classified as Schedule II, pemoline is listed as Schedule IV (non-narcotic.) In studies conducted on primates, pemoline fails to demonstrate a potential for self-administration.
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“A mechanism of some kind stands between us and almost every act of our lives.”
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