Finnish Type Amyloidosis - Genetics

Genetics

Lattice corneal dystrophy has two types:

• type I: with no systemic association. It is caused by mutations in TGFBI gene encoding keratoepithelin, which maps to chromosome 5q.

• type II or Finnish type amyloidosis: associated with manifestations of systemic amyloidosis due to accumulation of gelsolin. Associated conditions may include cutis laxa and ataxia.

• type III is also described which has an onset at age 70 to 90 years and is not associated with systemic amyloidosis.