Side Effects
Most fibrates can cause mild stomach upset and myopathy (muscle pain with CPK elevations). Since fibrates increase the cholesterol content of bile, they increase the risk for gallstones.
In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to renal failure. A powerful statin drug, cerivastatin (Lipobay), was withdrawn because of this complication. The less lipophilic statins are less prone to cause this reaction, and are probably safer when combined with fibrates.
Drug toxicity includes acute kidney injury.
Read more about this topic: Fibrate
Famous quotes containing the words side and/or effects:
“Populism is folkish, patriotism is not. One can be a patriot and a cosmopolitan. But a populist is inevitably a nationalist of sorts. Patriotism, too, is less racist than is populism. A patriot will not exclude a person of another nationality from the community where they have lived side by side and whom he has known for many years, but a populist will always remain suspicious of someone who does not seem to belong to his tribe.”
—John Lukacs (b. 1924)
“The hippie is the scion of surplus value. The dropout can only claim sanctity in a society which offers something to be dropped out of—career, ambition, conspicuous consumption. The effects of hippie sanctimony can only be felt in the context of others who plunder his lifestyle for what they find good or profitable, a process known as rip-off by the hippie, who will not see how savagely he has pillaged intricate and demanding civilizations for his own parodic lifestyle.”
—Germaine Greer (b. 1939)