Side Effects
Most fibrates can cause mild stomach upset and myopathy (muscle pain with CPK elevations). Since fibrates increase the cholesterol content of bile, they increase the risk for gallstones.
In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to renal failure. A powerful statin drug, cerivastatin (Lipobay), was withdrawn because of this complication. The less lipophilic statins are less prone to cause this reaction, and are probably safer when combined with fibrates.
Drug toxicity includes acute kidney injury.
Read more about this topic: Fibrate
Famous quotes containing the words side and/or effects:
“The most interesting thing which I heard of, in this township of Hull, was an unfailing spring, whose locality was pointed out to me on the side of a distant hill, as I was panting along the shore, though I did not visit it. Perhaps, if I should go through Rome, it would be some spring on the Capitoline Hill I should remember the longest.”
—Henry David Thoreau (1817–1862)
“If one judges love according to the greatest part of the effects it produces, it would appear to resemble rather hatred than kindness.”
—François, Duc De La Rochefoucauld (1613–1680)