Side Effects
Most fibrates can cause mild stomach upset and myopathy (muscle pain with CPK elevations). Since fibrates increase the cholesterol content of bile, they increase the risk for gallstones.
In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to renal failure. A powerful statin drug, cerivastatin (Lipobay), was withdrawn because of this complication. The less lipophilic statins are less prone to cause this reaction, and are probably safer when combined with fibrates.
Drug toxicity includes acute kidney injury.
Read more about this topic: Fibrate
Famous quotes containing the words side and/or effects:
“By that bedes side ther kneleth a may,
And she wepeth both nyght and day.
And by that beddes side ther stondith a ston,
‘Corpus Christi’wretyn theron.”
—Unknown. Corpus Christi Carol (l. 11–14)
“Like the effects of industrial pollution ... the AIDS crisis is evidence of a world in which nothing important is regional, local, limited; in which everything that can circulate does, and every problem is, or is destined to become, worldwide.”
—Susan Sontag (b. 1933)