Indications
Fibrates are used in accessory therapy in many forms of hypercholesterolemia, usually in combination with statins. Clinical trials do support their use as monotherapy agents. Fibrates reduce the number of non-fatal heart attacks, but do not improve all-cause mortality and are therefore indicated only in those not tolerant to statins.
Although less effective in lowering LDL, fibrates improve HDL and triglyceride levels by increasing HDL levels and decreasing triglyceride levels, and seem to improve insulin resistance when the dyslipidemia is associated with other features of the metabolic syndrome (hypertension and diabetes mellitus type 2). They are therefore used in many hyperlipidemias.
Read more about this topic: Fibrate
Famous quotes containing the word indications:
“The indications are that swearing preceded the development of cursing. That is, expletives, maledictions, exclamations, and imprecations of the immediately explosive or vituperative kind preceded the speechmaking and later rituals involved in the deliberate apportioning of the fate of an enemy. Swearing of the former variety is from the lips only, but the latter is from the heart. Damn it! is not that same as Damn you!”
—Ashley Montagu (b. 1905)
“It is difficult to write a paradiso when all the superficial indications are that you ought to write an apocalypse. It is obviously much easier to find inhabitants for an inferno or even a purgatorio.”
—Ezra Pound (1885–1972)
“You must labour to acquire that great and uncommon talent of hating with good breeding, and loving with prudence; to make no quarrel irreconcilable by silly and unnecessary indications of anger; and no friendship dangerous, in care it breaks, by a wanton, indiscreet, and unreserved confidence.”
—Philip Dormer Stanhope, 4th Earl Chesterfield (1694–1773)