Fgfs

Some articles on fgf, fgfs:

Fibroblast Growth Factor - Families
... In humans, 22 members of the FGF family have been identified, all of which are structurally related signaling molecules Members FGF1 through FGF10 all bind fibroblast ... FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functional differences compared to the FGFs ... homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs ...
Apical Ectodermal Ridge - Roles
... The FGFs secreted by the AER act upon the mesenchyme cells – including the zone of polarizing activity (ZPA) ... morphogenetic proteins (BMPs) that would normally block FGF expression in the AER ... sustain each other through a positive feedback loop involving FGFs, Shh, and Gremlin ...
Fibroblast Growth Factor - Receptors
... FGFs interact with the D2 and D3 domains, with the D3 interactions primarily responsible for ligand-binding specificity (see below) ... with the heparan sulfate binding site to prevent receptor activation in the absence of FGFs ... Each FGFR binds to a specific subset of the FGFs ...
Fibroblast Growth Factor
... Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development ... The FGFs are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction ... FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues ...
Fibroblast Growth Factor - Function
... FGFs are multifunctional proteins with a wide variety of effects they are most commonly mitogens but also have regulatory, morphological, and endocrine effects ... In the case of FGF, four receptor subtypes can be activated by more than twenty different FGF ligands ... Thus the functions of FGFs in developmental processes include mesoderm induction, antero-posterior patterning, limb development, neural induction and neural development, and in mature tissues/systems angiogenesis ...