Role in Disease
Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
Read more about this topic: Fas Ligand
Famous quotes containing the words role in, role and/or disease:
“Language makes it possible for a child to incorporate his parents’ verbal prohibitions, to make them part of himself....We don’t speak of a conscience yet in the child who is just acquiring language, but we can see very clearly how language plays an indispensable role in the formation of conscience. In fact, the moral achievement of man, the whole complex of factors that go into the organization of conscience is very largely based upon language.”
—Selma H. Fraiberg (20th century)
“Nothing is ever simple. What do you do when you discover you like parts of the role you’re trying to escape?”
—Marilyn French (b. 1929)
“It is said, proverbially, that happy is the doctor who is called in when the disease is on its way out.”
—François Rabelais (1494–1553)