Pharmacology
The above reactions are inhibited by bisphosphonates (used for osteoporosis).
Statin-induced rhabdomyolysis is due to the depletion of farnesyl-PPi, which leads to a depletion of CoQ in the electron transport chain of mitochondria, an organelle that is found in great numbers in myocytes.
Read more about this topic: Farnesyl Pyrophosphate