Fairholme may refer to:
- Fairholme Island, Nunavut, Canada
- Fairholme Range, Alberta, Canada
- Fairholm, Washington, United States
- Fairholme College, Australia
- Jeff Fairholm (b. 1965), retired professional football player
- Fairholme (John Street Home), Cadiz, Kentucky, a historic house listed on the National Register of Historic Places
- Fairholme (Newport R.I. mansion) a "cottage" in Newport County, Rhode Island