Factor Va

Some articles on factor, factor va:

Prothrombinase - Activation of Protein Precursors
... Both Factor X and Factor V circulate in the blood as inactive precursors prior to activation by the coagulation cascade ... The inactive zymogen Factor X consists of two chains, a light chain (136 residues) and a heavy chain (306 residues) ... (Gla domain) and two epidermal growth factor-like domains (EGF1 and EGF2) ...
Prothrombinase - Role in Disease
... Factor V deficiency, also called parahemophilia, is a rare autosomal recessive bleeding disorder with an approximate incidence of 1 in 1,000,000 ... Congenital Factor X deficiency is also extremely rare, affecting an estimated 1 in 1,000,000 ... A point mutation in the gene encoding Factor V can lead to a hypercoagulability disorder called Factor V Leiden ...
Prothrombinase - Inactivation
... Factor Va is inactivated following cleavage by activated protein C ... Activated protein C cleaves Factor Va in both its light and heavy chains ... Cleavage in the heavy chain reduces the ability of Factor V to bind to Factor Xa ...

Famous quotes containing the word factor:

    Children of the middle years do not do their learning unaffected by attendant feelings of interest, boredom, success, failure, chagrin, joy, humiliation, pleasure, distress and delight. They are whole children responding in a total way, and what they feel is a constant factor that can be constructive or destructive in any learning situation.
    Dorothy H. Cohen (20th century)