Factor Va

Some articles on factor, factor va:

Prothrombinase - Activation of Protein Precursors
... Both Factor X and Factor V circulate in the blood as inactive precursors prior to activation by the coagulation cascade ... The inactive zymogen Factor X consists of two chains, a light chain (136 residues) and a heavy chain (306 residues) ... contains an N-terminal γ-carboxyglutamic acid domain (Gla domain) and two epidermal growth factor-like domains (EGF1 and EGF2) ...
Prothrombinase - Role in Disease
... Factor V deficiency, also called parahemophilia, is a rare autosomal recessive bleeding disorder with an approximate incidence of 1 in 1,000,000 ... Congenital Factor X deficiency is also extremely rare, affecting an estimated 1 in 1,000,000 ... A point mutation in the gene encoding Factor V can lead to a hypercoagulability disorder called Factor V Leiden ...
Prothrombinase - Inactivation
... Factor Va is inactivated following cleavage by activated protein C ... Activated protein C cleaves Factor Va in both its light and heavy chains ... Cleavage in the heavy chain reduces the ability of Factor V to bind to Factor Xa ...

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