Causes
The most common antipsychotic associated with EPS is haloperidol used especially in schizophrenia. Other antidopaminergic drugs like the antiemetic metoclopramide or the tricyclic antidepressant amoxapine can also cause extrapyramidal side-effects. Another common cause are Selective Serotonin Reuptake Inhibitors (also known as SSRI), which indirectly decrease dopamine neurotransmission in the Substantia Nigra.
Extrapyramidal symptoms can also be caused by brain damage, as in athetotic cerebral palsy, which is involuntary writhing movements caused by prenatal or perinatal brain damage.Other common causes of extrapyramidal symptoms include encephalitis and meningitis. Extrapyramidal symptoms are distinct presentations of Japanese Encephalitis.
Read more about this topic: Extrapyramidal Symptoms