Extermination or exterminate may refer to:
- Pest control, elimination of insects or vermin
- Genocide, the deliberate and systematic destruction, in whole or in part, of an ethnic, racial, religious, or national group
- Extermination (arcade game), a 1989 arcade shooter game by Gottlieb
- Extermination (video game), a 2001 PlayStation 2 game by Deep Space
- Extermination (album), a 1995 by Torn Apart released by Life Sentence Records
- "Exterminate!" (song), a 1992 song by Snap!