List of Subunits
| Legend | General name | Domains | Human | Yeast (S. cerevisiae) | Archaea | MW (kD) | Human gene | Yeast gene |
|---|---|---|---|---|---|---|---|---|
| 1 | Csl4 | S1 RBD | hCsl4 | Csl4p/Ski4p | Csl4 | 21-32 | EXOSC1 | YNL232W |
| 2 | Rrp4 | S1/KH RBD | hRrp4 | Rrp4p | Rrp4 | 28-39 | EXOSC2 | YHR069C |
| 3 | Rrp40 | S1/KH RBD | hRrp40 | Rrp40p | (Rrp4)A | 27-32 | EXOSC3 | YOL142W |
| 4 | Rrp41 | RNase PH | hRrp41 | Rrp41p/Ski6p | Rrp41C | 26-28 | EXOSC4 | YGR195W |
| 5 | Rrp46 | RNase PH | hRrp46 | Rrp46p | (Rrp41)A,C | 25-28 | EXOSC5 | YGR095C |
| 6 | Mtr3 | RNase PH | hMtr3 | Mtr3p | (Rrp41)A,C | 24-37 | EXOSC6 | YGR158C |
| 7 | Rrp42 | RNase PH | hRrp42 | Rrp42p | Rrp42 | 29-32 | EXOSC7 | YDL111C |
| 8 | Rrp43 | RNase PH | OIP2 | Rrp43p | (Rrp42)A | 30-44 | EXOSC8 | YCR035C |
| 9 | Rrp45 | RNase PH | PM/Scl-75 | Rrp45p | (Rrp42)A | 34-49 | EXOSC9 | YDR280W |
| 10 | Rrp6 | RNase D | PM/Scl-100C | Rrp6pC | n/a | 84-100 | EXOSC10 | YOR001W |
| 11 | Rrp44 | RNase R | Dis3B,C
Dis3L1B,C |
Rrp44p/Dis3pC | n/a | 105-113 | DIS3
DIS3L1 |
YOL021C |
- A In archaea several exosome proteins are present in multiple copies, to form the full core of the exosome complex.
- B In humans, two different proteins can be associated in this position. In the cytoplasm of cells, Dis3L1 is associated with the exosome, whereas in the nucleus, Dis3 can bind to the core complex.
- C Contributes to the ribonucleolytic activity of the complex.
Read more about this topic: Exosome Complex
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