Excision Repair

Excision repair is a term applied to several DNA repair mechanisms. They remove the damaged nucleotides and are able to determine the correct sequence from the complementary strand of DNA.

Specific mechanisms include:

  • Base excision repair (BER), which repairs damage due to a single nucleotide caused by oxidation, alkylation, hydrolysis, or deamination;
  • Nucleotide excision repair (NER), which repairs damage affecting 2−30 nucleotide-length strands. These include bulky, helix distorting damage, such as thymine dimerization and other types of cyclobutyl dimerization caused by UV light as well as single-strand breaks. A specialized form of NER known as Transcription-Coupled Repair (TCR) deploys high-priority NER repair enzymes to genes that are being actively transcribed;
  • Mismatch repair (MMR), which corrects errors of DNA replication and recombination that result in mispaired nucleotides.


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DNA repair
Excision repair
  • Base excision repair/AP site
    • DNA glycosylase
    • Uracil-DNA glycosylase
    • Poly ADP ribose polymerase
  • Nucleotide excision repair/ERCC
    • XPA
    • XPB
    • XPC
    • XPD/ERCC2
    • XPE/DDB1
    • XPF/DDB1
    • XPG/ERCC5
    • ERCC1
    • RPA
    • RAD23A
    • RAD23B
    • Excinuclease
  • DNA mismatch repair
    • MLH1
    • MSH2
Other forms of repair
  • Transcription-coupled repair
    • ERCC6
    • ERCC8
  • Homology directed repair
  • Non-homologous end joining
    • Ku
  • Microhomology-mediated end joining
  • Postreplication repair
  • Photolyase
    • CRY1
    • CRY2
Other/ungrouped proteins
  • Ogt
  • PcrA
  • Proliferating Cell Nuclear Antigen
  • Homologous recombination
    • RecA
    • Sgs1
    • Slx4
Regulation
  • SOS box
  • SOS response
Other/ungrouped
  • 8-Oxoguanine
  • Adaptive response
  • Meiotic recombination checkpoint
  • RecF pathway
  • DNA helicase: BLM
  • WRN
  • FANC proteins: core protein complex
    • FANCA
    • FANCB
    • FANCC
    • FANCE
    • FANCF
    • FANCG
    • FANCL
    • FANCM
  • FANCD1
  • FANCD2
  • FANCI
  • FANCJ
  • FANCN
See also: DNA repair-deficiency disorder B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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