European route E 21 is a series of roads in Europe, part of the United Nations International E-road network.
It runs from Metz, France to Geneva, Switzerland. It meets the European route E 25, the E 50 and the E 411 at Metz, from where it departs. On its way to Geneva, it crosses the E 23 at Nancy, and also passes through Dijon. It enters Switzerland soon after and links with the E 25, the E 62 and the E 712 at Geneva, allowing further travel through Europe. It is 458 km (285 mi) long in total.
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