Eukaryotic Translation Elongation Factor 1 Alpha 1
Gene Ontology | |
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Molecular function | • translation elongation factor activity • GTPase activity • protein binding • GTP binding • protein kinase binding |
Cellular component | • nucleus • cytoplasm • cytosol • eukaryotic translation elongation factor 1 complex |
Biological process | • transcription, DNA-dependent • regulation of transcription, DNA-dependent • translation • translational elongation • gene expression • cellular protein metabolic process |
Sources: Amigo / QuickGO |
74.23 – 74.23 Mb
78.26 – 78.27 Mb
Elongation factor 1-alpha 1 (eEF1a1) is a protein that in humans is encoded by the EEF1A1 gene.
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty's syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes.
In addition to its role in translation, eEF1a has been shown to be play a central role in the nuclear export of proteins. VHL, PABP1 and other proteins containing a TD-NEM (Transcription Dependent Nuclear Export Motif) are exported by eEF1a in a manner that is dependent on ongoing RNA polymerase II (RNA PolII)-dependent transcription.
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