Eukaryotic Translation Elongation Factor 1 Alpha 1

Eukaryotic Translation Elongation Factor 1 Alpha 1

Identifiers Symbols EEF1A1; CCS-3; CCS3; EE1A1; EEF-1; EEF1A; EF-Tu; EF1A; GRAF-1EF; HNGC:16303; LENG7; PTI1; eEF1A-1 External IDs OMIM: 130590 MGI: 1096881 HomoloGene: 68181 ChEMBL: 1795120 GeneCards: EEF1A1 Gene

Gene Ontology
Molecular function translation elongation factor activity
GTPase activity
protein binding
GTP binding
protein kinase binding
Cellular component nucleus
cytoplasm
cytosol
eukaryotic translation elongation factor 1 complex
Biological process transcription, DNA-dependent
regulation of transcription, DNA-dependent
translation
translational elongation
gene expression
cellular protein metabolic process
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1915 13627 Ensembl ENSG00000156508 ENSMUSG00000037742 UniProt P68104 Q3TII3 RefSeq (mRNA) NM_001402 NM_010106 RefSeq (protein) NP_001393 NP_034236 Location (UCSC) Chr 6:
74.23 – 74.23 Mb Chr 9:
78.26 – 78.27 Mb PubMed search

Elongation factor 1-alpha 1 (eEF1a1) is a protein that in humans is encoded by the EEF1A1 gene.

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty's syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes.

In addition to its role in translation, eEF1a has been shown to be play a central role in the nuclear export of proteins. VHL, PABP1 and other proteins containing a TD-NEM (Transcription Dependent Nuclear Export Motif) are exported by eEF1a in a manner that is dependent on ongoing RNA polymerase II (RNA PolII)-dependent transcription.

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