Bisphenol A Binding
Further information: Bisphenol AThere is evidence that bisphenol A functions as an endocrine disruptor by binding strongly to ERR-γ. BPA seems to binds strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER). BPA binding to ERR-γ preserves its basal constitutive activity. It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.
Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the placenta, explaining reports of high bisphenol A accumulation there.
Read more about this topic: Estrogen-related Receptor Gamma
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