Esko is a Finnish masculine first name and may refer to:
- Esko Aho, a statesman and former Prime Minister of Finland.
- Esko Seppänen, a Finnish politician and Member of the European Parliament with the Left Alliance
- Esko Valtaoja, a Finnish astronomer and writer
- ESKO, the first Finnish-built computer
Esko may also refer to:
- Esko, an unincorporated settlement in Carlton County, Minnesota
- Esko, a graphic arts company.
- Esko, commuter rail systems around Prague, Czech Republic and in the Moravian-Silesian Region, Czech Republic.
- Esko Prague
- Esko Moravian-Silesian Region