Esch may refer to:
- Places
- Esch-sur-Alzette, the second largest city in Luxembourg
- Esch-sur-Sûre, a village in Luxembourg
- Esch, Bernkastel-Wittlich, a municipality in the district Bernkastel-Wittlich, Rhineland-Palatinate, Germany
- Esch, Vulkaneifel, a municipality in the district Vulkaneifel, Rhineland-Palatinate, Germany
- Esch, Netherlands, a former municipality now part of the municipality of Haaren
- ESCH, NASDAQ symbol for Eschelon Telecom, Inc.
- People
- En Esch
- Eric Esch, American boxer better known as Butterbean
- Jim Esch
- Johann Esch (died 1523), one of the first two Lutheran martyrs
- John J. Esch
- Marvin L. Esch (b. 1927), U.S. Representative from Michigan
- Nicolaus van Esch (1507-1578), Dutch theologian
- Hansjoachim von der Esch (1899-1976), German explorer