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- HEPPS (or EPPS), common names for the compound 3-propanesulfonic acid
- Edwards Personal Preference Schedule
- Energetic Particle and Plasma Spectrometer, an instrument aboard MESSENGER space probe that measures the charged particles in the magnetosphere around Mercury
- Epps effect, in econometrics and time series analysis, the phenomenon that the empirical correlation between the returns of two different stocks decreases as the sampling frequency of data increases
- Epps 1907 Monoplane, a pioneering aircraft built and flown in 1907 by Ben T. Epps
- Half-Sack Epps, a fictional character on the FX television series Sons of Anarchy, played by Johnny Lewis
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