Ephedrine - Chemistry

Chemistry

Ephedrine exhibits optical isomerism and has two chiral centres, giving rise to four stereoisomers. By convention the pair of enantiomers with the stereochemistry (1R,2S and 1S,2R) is designated ephedrine, while the pair of enantiomers with the stereochemistry (1R,2R and 1S,2S) is called pseudoephedrine.

Ephedrine is a substituted amphetamine and a structural methamphetamine analogue. It differs from methamphetamine only by the presence of a hydroxyl (OH). Amphetamines, however, are more potent and have additional biological effects.

The isomer which is marketed is (–)-(1R,2S)-ephedrine.

Ephedrine hydrochloride has a melting point of 187−188 °C.

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