EP300
| Gene Ontology | |
|---|---|
| Molecular function | • RNA polymerase II core promoter proximal region sequence-specific DNA binding • core promoter binding • RNA polymerase II activating transcription factor binding • p53 binding • DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • antigen binding • histone acetyltransferase activity • lysine N-acetyltransferase activity • protein binding • beta-catenin binding • transcription factor binding • zinc ion binding • acetyltransferase activity • transferase activity, transferring acyl groups • chromatin DNA binding • protein complex binding • activating transcription factor binding • glucocorticoid receptor binding • peroxisome proliferator activated receptor binding • metal ion binding • androgen receptor binding • mitogen-activated protein kinase binding • NF-kappaB binding |
| Cellular component | • histone acetyltransferase complex • chromatin • nucleus • nucleoplasm • transcription factor complex • nucleolus • cytoplasm • protein-DNA complex |
| Biological process | • negative regulation of transcription from RNA polymerase II promoter • response to hypoxia • somitogenesis • liver development • positive regulation of protein phosphorylation • transcription, DNA-dependent • regulation of transcription, DNA-dependent • apoptotic process • cell cycle • Notch signaling pathway • nervous system development • heart development • skeletal muscle tissue development • response to glucose stimulus • organ morphogenesis • positive regulation of glycoprotein biosynthetic process • N-terminal peptidyl-lysine acetylation • internal peptidyl-lysine acetylation • virus-host interaction • lung development • response to cobalt ion • positive regulation of protein binding • response to retinoic acid • positive regulation of collagen biosynthetic process • positive regulation of protein import into nucleus, translocation • cellular response to stress • response to drug • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of DNA binding • protein kinase B signaling cascade • response to estrogen stimulus • positive regulation by host of viral transcription • histone H4 acetylation • innate immune response • response to ethanol • positive regulation of axon extension • positive regulation of cell size • positive regulation of proteolysis • positive regulation of transcription from RNA polymerase II promoter • digestive tract development • positive regulation of protein secretion • positive regulation of sequence-specific DNA binding transcription factor activity • response to glucocorticoid stimulus • response to calcium ion • regulation of angiotensin metabolic process • positive regulation of sarcomere organization • regulation of androgen receptor signaling pathway • regulation of transcription from RNA polymerase II promoter in response to hypoxia • protein-DNA complex assembly • cellular response to hydrogen peroxide • response to fatty acid • cellular response to hypoxia |
| Sources: Amigo / QuickGO | |
41.49 – 41.58 Mb
81.59 – 81.65 Mb
E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body. It plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.
The p300 protein carries out its function by activating transcription. To be specific, p300 connects transcription factors, which are proteins that start the transcription process, with the complex of proteins that carry out transcription in the cell's nucleus. On the basis of this function, p300 is called a transcriptional coactivator. The p300 interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor interaction domain (RID), the CREB and MYB interaction domain (KIX), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD). The last four domains, KIX, TAZ1, TAZ2 and IBiD of p300, each bind tightly to a sequence spanning both transactivation domains 9aaTADs of transcription factor p53.
The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2.
EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16.
Read more about EP300: Function, Clinical Significance, Interactions