Mechanisms of Transition State Stabilization
These conformational changes also bring catalytic residues in the active site close to the chemical bonds in the substrate that will be altered in the reaction. After binding takes place, one or more mechanisms of catalysis lowers the energy of the reaction's transition state, by providing an alternative chemical pathway for the reaction. There are six possible mechanisms of "over the barrier" catalysis as well as a "through the barrier" mechanism:
Read more about this topic: Enzyme Catalysis
Famous quotes containing the words transition and/or state:
“Power ceases in the instant of repose; it resides in the moment of transition from a past to a new state, in the shooting of the gulf, in the darting to an aim.”
—Ralph Waldo Emerson (1803–1882)
“Me, rule? Me, place the State under my law, when my feeble reason no longer rules even myself!”
—Jean Racine (1639–1699)