ELK1

Identifiers Symbol ELK1 External IDs OMIM: 311040 MGI: 101833 HomoloGene: 3832 ChEMBL: 4453 GeneCards: ELK1 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription, DNA-dependent • Toll signaling pathway • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • innate immune response • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • nerve growth factor receptor signaling pathway • stress-activated MAPK cascade
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2002 13712 Ensembl ENSG00000126767 ENSMUSG00000009406 UniProt P19419 P41969 RefSeq (mRNA) NM_001114123 NM_007922 RefSeq (protein) NP_001107595 NP_031948 Location (UCSC) Chr X:
47.49 – 47.51 Mb Chr X:
20.93 – 20.95 Mb PubMed search

ETS domain-containing protein Elk-1 is a protein that in humans is encoded by the ELK1 gene. Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences. Elk1 plays important roles in various contexts, including long-term memory formation, drug addiction, Alzheimer's disease, Down syndrome, breast cancer, and depression.