Elisa may refer to:
- Elisa (given name)
- ELISA or Enzyme-Linked Immunosorbent Assay, a biochemical technique
- Evolved Laser Interferometer Space Antenna (eLISA), a proposed configuration for a space based gravitational wave detector
- ELISA (satellite) French military satellite series
- Elisa (Japanese singer) (born 1985), Japanese singer and model
- Elisa (Italian singer) (born 1977), Italian singer and songwriter
- Elisa (album), a 2002 compilation album by Italian singer Elisa
- Elisa (company), a Finnish telecommunications company
- An alternative spelling of Eliza (Cherubini), a 1794 opera by Cherubini
- Élisa (film), a 1995 French film starring Gérard Depardieu and Vanessa Paradis
- Elissa, another name of Dido, the queen of Carthage in Greek mythology