Professional Boxing Record
| 64 Wins (55 knockouts), 11 Losses, 1 Draw | |||||||
| Res. | Record | Opponnent | Type | Round | Date | Location | Notes |
| Win | 64-11-1 | Iván Popoca | TKO | 8(10) | 2012-07-13 | UIC Pavilion, Chicago, Illinois, United States | |
| Win | 63–11-1 | Sammy Ventura | TKO | 2 (10) | 2011-11-26 | Campo Futbol Colosio, Playa del Carmen, Quintana Roo, Mexico | |
| Lose | 62–11-1 | Jorge Paez Jr | UD | 12 (12) | 2011-03-25 | Parque Vicente Guerrero, Mexicali, Baja California | |
| Win | 62–10-1 | Daniel Eduardo Yocupicio | TKO | ? (10) | 2010-08-07 | Estadio Hector Espino, Hermosillo, Sonora | |
| Lose | 61–10-1 | Alfonso Gomez | RTD | 6 (12) | 2010-03-13 | Cowboys Stadium, Arlington, Texas | For WBC Continental Americas welterweight title. |
| Win | 61–9-1 | Carlos Urias | TKO | 2 (8) | 2009-09-12 | El Palenque de la Feria, Tepic, Nayarit | |
| Win | 60–9-1 | Christian Solano | TKO | 3 (10) | 2009-08-22 | Auditorio Unidad Deportiva, Los Cabos, Baja California Sur | |
| Win | 59–9-1 | Roberto Valenzuela | KO | 6 (10) | 2009-07-25 | Palenque del Recinto Ferial, Nuevo Vallarta, Nayarit | |
| Win | 58–9-1 | James Wayka | TKO | 2 (10) | 2009-01-17 | Palenque del FEX, Mexicali, Baja California | |
| Lose | 57–9-1 | Sebastian Andres Lujan | UD | 10 | 2008-07-30 | Sycuan Resort & Casino, El Cajon, California | |
| Win | 57–8-1 | Adan Casillas | TKO | 6 (10) | 2007-10-27 | Palenque del FEX, Mexicali, Baja California | |
| Lose | 56–8-1 | Ricky Hatton | KO | 4 (12) | 2007-06-23 | Thomas & Mack Center, Las Vegas, Nevada | For The Ring light welterweight title. |
| Win | 56–7-1 | Herman Ngoudjo | SD | 12 | 2007-01-20 | Paris Las Vegas, Las Vegas, Nevada | Won NABF light welterweight title |
| Win | 55–7-1 | Rolando Reyes | UD | 12 | 2006-02-04 | Don Haskins Convention Center, El Paso, Texas | |
| Win | 54–7-1 | Diego Corrales | KO | 4 (12) | 2005-10-08 | Thomas & Mack Center, Las Vegas, Nevada | |
| Lose | 53-7–1 | Diego Corrales | TKO | 10 (12) | 2005-05-07 | Mandalay Bay Resort & Casino, Las Vegas, Nevada | Lost WBC & The Ring lightweight titles. For WBO lightweight title. |
| Win | 53-6–1 | Julio Diaz | TKO | 10 (12) | 2005-03-05 | Mandalay Bay Resort & Casino, Las Vegas, Nevada | Retained WBC & The Ring lightweight titles. |
| Win | 52-6–1 | Joel Casamayor | SD | 12 | 2004-12-04 | Mandalay Bay Resort & Casino, Las Vegas, Nevada | Retained WBC & The Ring lightweight titles. |
| Win | 50-6–1 | Juan Lazcano | UD | 12 | 2004-06-05 | MGM Grand Garden Arena, Las Vegas, Nevada | Won vacant WBC & The Ring lightweight titles. |
| Win | 49-6–1 | Gustavo Corral | KO | 5 (10) | 2003-06-14 | Honda Center, Anaheim, California | |
| Lose | 48-6–1 | Floyd Mayweather Jr | UD | 12 | 2002-12-07 | Mandalay Bay Resort & Casino, Las Vegas, Nevada | For WBC & The Ring lightweight titles. |
| Win | 48-5–1 | Verdell Smith | KO | 3 (10) | 2002-08-03 | Centro de Usos Multiples, Hermosillo, Sonora | |
| Lose | 47-5–1 | Floyd Mayweather Jr | UD | 12 | 2002-04-20 | MGM Grand, Las Vegas, Nevada | Lost WBC lightweight title. For vacant The Ring lightweight title. |
| Win | 47-4–1 | Juan Angel Macias | TKO | 8 (10) | 2002-01-25 | AVI Resort & Casino, Laughlin, Nevada | |
| Win | 46-4–1 | Fred Ladd | TKO | 4 (10) | 2001-08-24 | Mexicali, Baja California | |
| Win | 45-4–1 | Sung-Ho Yuh | KO | 1 (12) | 2001-06-16 | Centro de Usos Multiples, Hermosillo, Sonora | Retained WBC lightweight title. |
| Win | 44-4–1 | Cesar Bazan | TKO | 6 (12) | 2001-01-20 | MGM Grand, Las Vegas, Nevada | Retained WBC lightweight title. |
| Draw | 43-4–1 | Stevie Johnston | PTS | 12 | 2000-09-15 | Pepsi Center, Denver, Colorado | Retained WBC lightweight title. |
| Win | 43-4–0 | Stevie Johnston | MD | 12 | 2000-06-17 | MGM Grand, Las Vegas, Nevada | Won WBC lightweight title. |
| Win | 42-4–0 | Steve Quinonez | UD | 10 | 2000-04-08 | Blancas Bazaar, Imperial Beach, California | |
| Win | 41-4–0 | Jorge Páez | KO | 5 (12) | 1999-10-16 | Plaza Calafia, Mexicali, Baja California | |
| Win | 40-4–0 | Sandro Marcos | KO | 8 (12) | 1999-08-14 | Guaymas, Sonora, Mexico | Won Mexican super featherweight title. |
| Win | 39-4–0 | Cristino Mota | KO | 4 (?) | 1999-07-10 | Mexicali, Baja California | |
| Win | 38-4–0 | Pablo Valenzuela | KO | 4 (?) | 1999-06-04 | Mexicali, Baja California | |
| Win | 37-4–0 | Julian Romero | UD | 6 | 1999-04-01 | Don Haskins Convention Center, El Paso, Texas | |
| Win | 36-4–0 | Eduardo Montes | KO | 3 (?) | 1999-02-19 | Mexicali, Baja California | |
| Lose | 35-4–0 | Julio Alvarez | TKO | 10 (12) | 1998-10-03 | Mexico City, Distrito Federal | Lost Mexican super featherweight title. |
| Win | 35-3–0 | Julio Sanchez Leon | TKO | 8 (12) | 1998-04-17 | Mexicali, Baja California | Retained Mexican super featherweight title. |
| Win | 34-3–0 | Hector Javier Marquez | TKO | 10(12) | 1997-09-12 | Guaymas, Sonora | Retained Mexican super featherweight title. |
| Win | 33-3–0 | Rafael Olvera | KO | 7 (12) | 1997-07-04 | Gimnasio Municipal "Jose Neri Santos", Ciudad Juarez, Chihuahua | Won Mexican super featherweight title. |
| Win | 32-3–0 | Javier Renteria | KO | 1 (?) | 1997-03-08 | Stadio El Ferrocarel, Mexicali, Baja California | |
| Win | 31-3–0 | Jesus Castaneda | KO | 2 (?) | 1997-01-01 | Mexicali, Baja California | |
| Win | 30-3–0 | Jaime Fernandez | KO | 1 (?) | 1996-12-13 | Mexicali, Baja California | |
| Win | 29-3–0 | Roberto Valenzuela | KO | 6 (6) | 1996-10-12 | Honda Center, Anaheim, California | |
| Win | 28-3–0 | Jose Luis Montes | KO | 7 (?) | 1996-09-20 | Mexicali, Baja California | |
| Win | 27-3–0 | Jesus Arce | KO | 1 (12) | 1996-08-15 | Mexicali, Baja California | |
| Lose | 26-3–0 | Javier Jauregui | TKO | 10 (12) | 1996-05-09 | Guadalajara, Jalisco | |
| Win | 26-2–0 | Carlos Madrid | KO | 2 (?) | 1996-03-15 | Mexicali, Baja California | |
| Win | 25-2–0 | Cornelio Lopez | KO | 4 (?) | 1995-12-08 | Mexicali, Baja California | |
| Win | 24-2–0 | Alfredo Curiel | KO | 4 (?) | 1995-09-29 | Mexicali, Baja California | |
| Win | 23-2–0 | Ramon Soto | KO | 3 (?) | 1995-04-07 | Mexicali, Baja California | |
| Lose | 22-2–0 | Javier Jauregui | TKO | 10 (12) | 1996-05-09 | Guadalajara, Jalisco | |
| Win | 21-1–0 | Alfredo Curiel | TKO | 6 (?) | 1994-08-26 | Empalme, Sonora | |
| Win | 20-1–0 | Francisco Valdez | KO | 1 (?) | 1994-03-18 | Mexicali, Baja California | |
| Lose | 19-1–0 | Cesar Soto | TKO | 2 (12) | 1993-07-09 | Ciudad Juarez, Chihuahua | |
| Win | 18-0–0 | Lucilo Nolasco | KO | 2 (?) | 1993-04-30 | Mexicali, Baja California | |
| Win | 17-0–0 | Juan Carlos Salazar | KO | 1 (?) | 1993-03-05 | Mexicali, Baja California | |
| Win | 16-0–0 | Ascencion Lugo | KO | 2 (?) | 1992-12-11 | Hermosillo, Sonora | |
| Win | 15-0–0 | Francisco Valdez | TD | 6 (?) | 1992-10-02 | Tijuana, Baja California | |
| Win | 14-0–0 | Jorge Castro | KO | 2 (?) | 1992-09-04 | Mexicali, Baja California | |
| Win | 13-0–0 | Rigoberto Felix | KO | 3 (?) | 1992-08-07 | Mexicali, Baja California | |
| Win | 12-0–0 | Ramon Acuna | KO | 2 (?) | 1992-06-20 | Mexicali, Baja California | |
| Win | 11-0–0 | Ramon Arreola | KO | 3 (?) | 1992-05-29 | Tijuana, Baja California | |
| Win | 10-0–0 | Cesar Huizar | KO | 1 (?) | 1992-03-30 | Tijuana, Baja California | |
| Win | 9-0–0 | Ramiro Dunton | KO | 5 (?) | 1991-11-22 | Mexicali, Baja California | |
| Win | 8-0–0 | Jose Manjarrez | KO | 7 (?) | 1991-09-06 | Mexicali, Baja California | |
| Win | 7-0–0 | Miguel Angel Ramirez | KO | 4 (?) | 1991-08-19 | Tijuana, Baja California | |
| Win | 6-0–0 | Victor Mendoza | KO | 4 (?) | 1991-04-08 | Tijuana, Baja California | |
| Win | 5-0–0 | Raul Contreras | KO | 3 (?) | 1991-03-21 | Mexicali, Baja California | |
| Win | 4-0–0 | Jesus Escobar | KO | 1 (?) | 1990-12-21 | Mexicali, Baja California | |
| Win | 3-0–0 | Jose Alvarez | KO | 2 (?) | 1990-10-01 | Tijuana, Baja California | |
| Win | 2-0–0 | Manolo Ramirez | KO | 2 (?) | 1990-06-23 | Mexicali, Baja California | |
| Win | 1-0–0 | Ricardo Contreras | KO | 2(4) | 1990-05-04 | Mexicali, Baja California | Castillo's professional debut at 16 years old. |
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