El Chapo may refer to:
- El Chapo de Sinaloa: born Ernesto Pérez, is a Mexican norteño/banda singer.
- Joaquín Guzmán: nicknamed El Chapo Guzmán, ("Shorty Guzmán"), the head of the Sinaloa Cartel, an international drug trafficking organization.
- Fausto Isidro Meza Flores: nicknamed El Chapo Isidro, the high-ranking leader of a Beltran Leyva Cartel cell.