Efflux Inhibitors
Several trials are currently being conducted to develop drugs that can be co-administered with antibiotics to act as inhibitors for the efflux-mediated extrusion of antibiotics. None of the efflux inhibitors tested is yet in clinical use. However, some of them are used to determine the efflux prevalence in clinical isolates. Its shown that Verapamil can inhibit P-glycoprotein mediated efflux which can increase oral absorption of some compounds. Some chemicals found in plants have potential as reflex pump inhibitors. Chemicals such as Capsanthin and capsorubin, carotenoids isolated from paprika; the flavonoids, rotenone, chrysin, phloretin and sakuranetin.
Read more about this topic: Efflux (microbiology)
Famous quotes containing the word efflux:
“But genius looks forward: the eyes of man are set in his forehead, not in his hindhead: man hopes: genius creates. Whatever talents may be, if man create not, the pure efflux of the Deity is not his;Mcinders and smoke there may be, but not yet flame.”
—Ralph Waldo Emerson (1803–1882)