Others
- Edward B. Lewis (1918–2004), American geneticist and Nobel Prize winner
- Edward Gardner Lewis (1869–1950), American promoter, publisher, and political activist
- Edward J. Lewis (1937–2006), American businessman and real estate developer from Pittsburgh
- Ed Lewis, British Committee of 100 signatory
- Edward Lewis (producer), film producer
- Edward Lewis (minister) (1831–1913), New Zealand bootmaker and Church of Christ minister
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