EDI may refer to:
- UCL Eastman Dental Institute, a dental school in London, United Kingdom forming part of University College London
- Efficient Drivetrains Inc
- Electronic Data Interchange, a particular set of standards for computer-to-computer exchange of information
- EDI register, Extended Destination Index register in the x86 microprocessor architecture
- Edinburgh Airport, IATA code
- Entrepreneurship Development Institute, a non-profit organisation in India
- Environmental Dynamics Inc., an aeration system manufacturer and installer.
- Economic Development Institute, a previous name of the World Bank Institute
- Eating Disorder Inventory, a self-report questionnaire used to assess the presence of eating disorders
- Electrodeionization, a water purification process
- E.D.I. Mean American rap artist
- Downer EDi, an Australian company
- Emergency Doorway Identifiers
- EDI, the Normandy SR-2's onboard artificial intelligence program in Mass Effect