EC 1.8 - EC 1.99 Other Enzymes Using O2 As Oxidant - EC 1.99.2 Oxygenases (now Covered By EC 1.13)

EC 1.99.2 Oxygenases (now Covered By EC 1.13)

  • EC 1.99.2.1: deleted, now *EC 1.13.11.12
  • EC 1.99.2.2: deleted, now *EC 1.13.11.1
  • EC 1.99.2.3: deleted, now *EC 1.13.11.3
  • EC 1.99.2.4: deleted, now *EC 1.13.11.4
  • EC 1.99.2.5: deleted, now *EC 1.13.11.5
  • EC 1.99.2.6: deleted, now *EC 1.13.99.1
Proteins: enzymes
Topics
  • Active site
  • Allosteric regulation
  • Binding site
  • Catalytically perfect enzyme
  • Coenzyme
  • Cofactor
  • Cooperativity
  • EC number
  • Enzyme catalysis
  • Enzyme inhibitor
  • Enzyme kinetics
  • Lineweaver–Burk plot
  • Michaelis–Menten kinetics
  • List of enzymes
Types
  • EC1 Oxidoreductases/list
  • EC2 Transferases/list
  • EC3 Hydrolases/list
  • EC4 Lyases/list
  • EC5 Isomerases/list
  • EC6 Ligases/list
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
  • 3-hydroxyacyl-CoA dehydrogenase
  • 3-hydroxybutyryl-CoA dehydrogenase
  • Alcohol dehydrogenase
  • Aldo-keto reductase
    • 1A1
    • 1B1
    • 1B10
    • 1C1
    • 1C3
    • 1C4
    • 7A2
  • Aldose reductase
  • Beta-Ketoacyl ACP reductase
  • Carbohydrate dehydrogenases
  • Carnitine dehydrogenase
  • D-malate dehydrogenase (decarboxylating)
  • DXP reductoisomerase
  • Glucose-6-phosphate dehydrogenase
  • Glycerol-3-phosphate dehydrogenase
  • HMG-CoA reductase
  • IMP dehydrogenase
  • Isocitrate dehydrogenase
  • Lactate dehydrogenase
  • L-threonine dehydrogenase
  • L-xylulose reductase
  • Malate dehydrogenase
  • Malate dehydrogenase (decarboxylating)
  • Malate dehydrogenase (NADP+)
  • Malate dehydrogenase (oxaloacetate-decarboxylating)
  • Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
  • Phosphogluconate dehydrogenase
  • Sorbitol dehydrogenase
  • Hydroxysteroid dehydrogenase: 3 Beta
    • 3-beta-HSD
    • NSDHL
  • 11 Beta
    • HSD11B1
    • HSD11B2
  • 17 Beta
1.1.2: cytochrome acceptor
  • D-lactate dehydrogenase (cytochrome)
  • D-lactate dehydrogenase (cytochrome c-553)
  • Mannitol dehydrogenase (cytochrome)
1.1.3: oxygen acceptor
  • Glucose oxidase
  • L-gulonolactone oxidase
  • Xanthine oxidase
1.1.4: disulfide as acceptor
  • Vitamin K epoxide reductase
  • Vitamin-K-epoxide reductase (warfarin-insensitive)
1.1.5: quinone/similar acceptor
  • Malate dehydrogenase (quinone)
  • Quinoprotein glucose dehydrogenase
1.1.99: other acceptors
  • Choline dehydrogenase
  • L2HGDH
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Aldehyde/oxo oxidoreductases (EC 1.2)
1.2.1: NAD or NADP
  • Aldehyde dehydrogenase: Acetaldehyde dehydrogenase
    • ALDH2
  • Long-chain-aldehyde dehydrogenase
  • Glyceraldehyde 3-phosphate dehydrogenase
1.2.2: cytochrome
  • Formate dehydrogenase (cytochrome)
1.2.3: oxygen
  • Aldehyde oxidase
1.2.4: disulfide
  • Oxoglutarate dehydrogenase
  • Pyruvate dehydrogenase
  • Branched-chain alpha-keto acid dehydrogenase complex
    • BCKDHA
    • BCKDHB
    • DBT
    • DLD
1.2.7: iron-sulfur protein
  • Pyruvate synthase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: CH-CH oxidoreductases (EC 1.3)
1.3.1: NAD/NADP acceptor
  • Enoyl-acyl carrier protein reductase/Enoyl ACP reductase
  • 7-Dehydrocholesterol reductase
  • Biliverdin reductase
  • 2,4 Dienoyl-CoA reductase
1.3.3: Oxygen acceptor
  • Dihydroorotate dehydrogenase
  • Coproporphyrinogen III oxidase
  • Protoporphyrinogen oxidase
1.3.5: Quinone
  • Succinate dehydrogenase
    • SDHA
    • SDHB
    • SDHC
    • SDHD
1.3.99: Other acceptors
  • Fumarate reductase
  • Butyryl CoA dehydrogenase
  • Acyl CoA dehydrogenase
    • ACADSB
    • ACADS
  • 5α-reductase
    • SRD5A1
    • SRD5A2
    • SRD5A3
  • Glutaryl-CoA dehydrogenase
  • Isovaleryl coenzyme A dehydrogenase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
CH-NH2 oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
1.4.1: NAD/NADP acceptor
  • Glutamate dehydrogenase
    • GLUD1
    • GLUD2
  • Glutamate synthase (NADPH)
1.4.3: oxygen acceptor
  • D-amino acid oxidase
  • Amine oxidase
  • Lysyl oxidase
  • Monoamine oxidase
1.4.4: disulfide acceptor
  • Glycine decarboxylase complex
1.4.99: other acceptors
  • D-amino acid dehydrogenase
  • Amine dehydrogenase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: CH-NH (EC 1.5)
1.5.1: NAD or NADP acceptor
  • Dihydrofolate reductase
  • Saccharopine dehydrogenase
  • Methylenetetrahydrofolate reductase
1.5.3: oxygen acceptor
  • Dihydrobenzophenanthridine oxidase
  • Sarcosine oxidase
  • Proline oxidase
1.5.5: quinone acceptor
  • Electron-transferring-flavoprotein dehydrogenase
1.5.99
  • Sarcosine dehydrogenase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: NADH or NADPH (EC 1.6)
1.6.1: NAD/NADP
  • NAD(P)+ transhydrogenase (B-specific)
1.6.2: Heme
  • Methemoglobin reductase
  • NADPH-hemoprotein reductase/Cytochrome P450 reductase
  • NADPH-cytochrome-c2 reductase
  • Leghemoglobin reductase
1.6.3: Oxygen
  • NADPH oxidase
    • P91-PHOX
    • Neutrophil cytosolic factor 1
    • Neutrophil cytosolic factor 2
    • Neutrophil cytosolic factor 4
  • dual oxidase
    • Dual oxidase 1
    • Dual oxidase 2
1.6.5: Quinone or similar
  • NADH dehydrogenase
1.6.6: Nitrogenous group
  • Trimethylamine-N-oxide reductase
1.6.99: other
  • NADH dehydrogenase (quinone)
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: nitrogenous donor (EC 1.7)
1.7.1
  • GMP reductase
1.7.2
  • Nitrite reductase (NO-forming)
1.7.3
  • Urate oxidase
1.7.7
  • Ferredoxin-nitrite reductase
1.7.99
  • Hydroxylamine reductase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: sulfur oxidoreductases (EC 1.8)
1.8.1: NAD or NADP
  • Dihydrolipoamide dehydrogenase
  • Glutathione reductase
  • Thioredoxin reductase
1.8.2: cytochrome
  • Sulfite dehydrogenase
  • Thiosulfate dehydrogenase
1.8.3: oxygen
  • Sulfite oxidase
1.8.4: disulfide
  • Glutathione-homocystine transhydrogenase
1.8.5: quinone
  • Glutathione dehydrogenase (ascorbate)
1.8.98: Other, known
  • CoB-CoM heterodisulfide reductase
1.8.99: Other
  • Sulfite reductase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: diphenol family (EC 1.10)
1.10.1
  • Trans-acenaphthene-1,2-diol dehydrogenase
1.10.2
  • Coenzyme Q - cytochrome c reductase
1.10.3
  • Catechol oxidase
  • Laccase
1.10.99
  • Cytochrome b6f complex
Other
  • Alternative oxidase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: peroxidases (EC 1.11)
1.11.1.1-14
  • Catalase
  • Cytochrome c peroxidase
  • Eosinophil peroxidase
  • Glutathione peroxidase
    • GPX 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • Horseradish peroxidase
  • Lactoperoxidase
  • Myeloperoxidase
  • Thyroid peroxidase
  • Deiodinase
    • Iodothyronine deiodinase
    • Iodotyrosine deiodinase
1.11.1.15 (peroxiredoxin)
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: monooxygenases (EC 1.13)
1.13.11: two atoms of oxygen
  • lipoxygenase: Arachidonate 5-lipoxygenase
  • Arachidonate 12-lipoxygenase/ALOX12
  • Arachidonate 8-lipoxygenase
  • Arachidonate 15-lipoxygenase/ALOX15
  • Linoleate 11-lipoxygenase
  • other dioxygenase: Catechol dioxygenase
  • Homogentisate 1,2-dioxygenase
  • Cysteine dioxygenase
  • 4-Hydroxyphenylpyruvate dioxygenase
  • Indoleamine 2,3-dioxygenase
1.13.12: one atom of oxygen
  • Firefly luciferase
1.13.99: other
  • Inositol oxygenase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11: 2-oxoglutarate
  • Prolyl hydroxylase
  • Lysyl hydroxylase
1.14.13: NADH or NADPH
  • Flavin-containing monooxygenase
    • FMO1
    • FMO2
    • FMO3
    • FMO4
    • FMO5
  • Nitric oxide synthase
    • NOS1
    • NOS2
    • NOS3
  • Cholesterol 7 alpha-hydroxylase
  • Methane monooxygenase
  • 3A4
  • Lanosterol 14 alpha-demethylase
1.14.14: reduced flavin or flavoprotein
  • 19A1
  • 2D6
  • 2E1
1.14.15: reduced iron-sulfur protein
  • 11B1
  • 11B2
  • 11A1
1.14.16: reduced pteridine (BH4 dependent)
  • Phenylalanine hydroxylase
  • Tyrosine hydroxylase
  • Tryptophan hydroxylase
1.14.17: reduced ascorbate
  • Dopamine beta hydroxylase
1.14.18-19: other
  • Tyrosinase
  • Stearoyl-CoA desaturase-1
1.14.99 - miscellaneous
  • Cyclooxygenase
  • Heme oxygenase (HMOX1)
  • Squalene monooxygenase
  • 17A1
  • 21A2
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Other oxidoreductases (EC 1.15-1.21)
1.15: Acting on superoxide as acceptor
  • Superoxide dismutase
    • SOD1
    • SOD2
    • SOD3
1.16: Oxidizing metal ions
  • Ceruloplasmin
1.17: Acting on CH or CH2 groups
  • Xanthine oxidase
  • Ribonucleotide reductase
  • 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
1.18: Acting on iron-sulfur proteins as donors
  • Nitrogenase
1.19: Acting on reduced flavodoxin as donor
  • Nitrogenase (flavodoxin)
1.20: Acting on phosphorus or arsenic in donors
  • Glutaredoxin
    • GLRX
    • GLRX2
    • GLRX3
    • GLRX5
1.21: Acting on X-H and Y-H to form an X-Y bond
  • Isopenicillin-N synthase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6

Read more about this topic:  EC 1.8, EC 1.99 Other Enzymes Using O2 As Oxidant

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