Eastbourne by-election may refer to one of
- Eastbourne by-election, 1925 (Sir George Ambrose Lloyd elevated to the peerage)
- Eastbourne by-election, 1932 (death of Edward Marjoribanks)
- Eastbourne by-election, 1935 (death of John Slater)
- Eastbourne by-election, 1990 (death of Ian Gow)