Destinations
Dutch Antilles Express serve the following destinations, as at December 2012:
| City | Country | Airport | Notes |
|---|---|---|---|
| Oranjestad | Aruba | Queen Beatrix International Airport | |
| Willemstad | Curacao | Hato International Airport | Hub |
| Santo Domingo | Dominican Republic | Las Américas International Airport | |
| Kralendijk | Netherlands | Flamingo International Airport | |
| Miami | United States | Miami International Airport | |
| Paramaribo | Suriname | Johan Adolf Pengel International Airport | |
| Philipsburg | Sint Maarten | Princess Juliana International Airport | |
| Caracas | Venezuela | Simón Bolívar International Airport (Venezuela) | |
| Barquisimeto | Venezuela | Jacinto Lara International Airport | Beginning 2013 |
| Maracaibo | Venezuela | La Chinita International Airport | |
| Valencia | Venezuela | Arturo Michelena International Airport | |
| Manaus | Brazil | Eduardo Gomes International Airport | Beginning 2013 |
| Port-au-Prince | Haiti | Toussaint Louverture International Airport | |
| La Habana | Cuba | José Martí International Airport | Beginning 2012 |
| Bogotá | Colombia | El Dorado International Airport | Beginning 2013 |
| Cartagena | Colombia | Rafael Núñez International Airport | Beginning 2013 |
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