Duffie or Duffié may refer to:
- Alfred N. Duffié (1833–1880), French-American soldier and diplomat who served in the Crimean War and the American Civil War
- Darrell Duffie, Canadian economist
- Grace Duffie Boylan (1861–1935), American writer
- John Duffie (born 1945), former pitcher in Major League Baseball
- Kieran Duffie (born 1992), professional Football player
- Matt Duffie (born 1990), professional rugby league player
- Paul Duffie (born 1951), former politician, lawyer and judge in the Canadian province of New Brunswick
- William R. Duffie (died 2000), forestry engineer and political figure in New Brunswick, Canada
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