Nature As Source of Drugs
Despite the rise of combinatorial chemistry as an integral part of lead discovery process, natural products still play a major role as starting material for drug discovery. A report was published in 2007, covering years 1981-2006 details the contribution of biologically occurring chemicals in drug development. According to this report, of the 974 small molecule new chemical entities, 63% were natural derived or semisynthetic derivatives of natural products. For certain therapy areas, such as antimicrobials, antineoplastics, antihypertensive and anti-inflammatory drugs, the numbers were higher. In many cases, these products have been used traditionally for many years.
Natural products may be useful as a source of novel chemical structures for modern techniques of development of antibacterial therapies.
Despite the implied potential, only a fraction of Earth’s living species has been tested for bioactivity.
Read more about this topic: Drug Discovery
Famous quotes containing the words nature, source and/or drugs:
“We call contrary to nature what happens contrary to custom; nothing is anything but according to nature, whatever it may be, Let this universal and natural reason drive out of us the error and astonishment that novelty brings us.”
—Michel de Montaigne (1533–1592)
“By recognizing a favorable opinion of yourself, and taking pleasure in it, you in a measure give yourself and your peace of mind into the keeping of another, of whose attitude you can never be certain. You have a new source of doubt and apprehension.”
—Charles Horton Cooley (1864–1929)
“Razors pain you;
Rivers are damp;
Acids stain you;
And drugs cause cramp.
Guns aren’t lawful;
Nooses give;
Gas smells awful;
You might as well live.”
—Dorothy Parker (1893–1967)