S
- Sachs, Eddie (1927–1964), Indy 500
- Santander, Sergio (1954–1987), Chilean Formula 3 race, Las Vizcachas, Santiago
- Savage, Swede (1946–1973), Indy 500
- Scarfiotti, Ludovico (1933–1968), Hillclimb, Rossfeld
- Schell, Harry (1921–1960), Formula 1 testing, Silverstone
- Schindler, Bill (1909–1952), Allentown
- Schillinger Josef (? - 1968) 1968 Belgian GP, Spa
- Schlesser, Jo (1928–1968), French GP, Rouen
- Schoonover, Terry (1952–1984), NASCAR WCP race, Atlanta
- Scott Brown, Archie (1927–1958), Sport Car Race at Circuit de Spa-Francorchamps
- Seaman, Richard (1913–1939), Belgian GP, Spa
- Senna, Ayrton (1960–1994), San Marino GP, Imola
- Shanahan, Neil (1979–1999), UK Formula Ford, Oulton Park
- Shepherd, Lee (1944–1985), Pro-Stock Drag testing, Ardmore
- Siffert, Jo (1936–1971), Non Championship F1 race, Brands Hatch
- Skeen, Buren (1936–1965), NASCAR Southern 500 at Darlington
- Smiley, Gordon (1946–1982), Indy 500 qualifying
- Smith, Larry (1942–1973), Talladega 500 NASCAR race, Talladega
- Snell, William (1914–1956), SCCA Club regional sportscar race, Arcata-Eureka Airport, death would lead to the Snell Memorial Foundation standard for helmets
- Solana, Moisés (1936–1969), Hillclimb Valle de Bravo - Bosencheve, México
- Sommer, Raymond (1906–1950), Non Championship Formula 1 race, Cadours
- Sondermann, Gustavo (1982–2011), Stock Car Brasil race (Copa Chevrolet Montana category), Autódromo José Carlos Pace
- Spangler, Lester (1906–1933) Indy 500
- Spence, Mike (1936–1968), Indy 500 practice
- Sperafico, Rafael (1981–2007), Stock Car Brasil race (Stock Car Light category), Autódromo José Carlos Pace
- Stacey, Alan (1933–1960), Belgian GP, Spa
- Stanley, Robbie (1967–1994), Sprint Car race, Winchester Speedway
- Stewart, Max (1935–1977), Practice for 1977 Australian Drivers Championship Race, Calder Park Raceway, Victoria, Australia
- Stewart, Tom (1959-7/6/1980), North American Formula Atlantic racing series, Lime Rock, CT, car crashed into a safety barrier during a practice run.
- Stommelen, Rolf (1943–1983), Sports Car race, Riverside International Raceway
- Surtees, Henry (1991–2009), Formula 2, Brands Hatch
- Sweikert, Bob (1926–1956), Sprint Car race, Salem
Read more about this topic: Driver Deaths In Motorsport