DRE may refer to:
- Dre (album, 2010 album by American rapper Soulja Boy Tell 'Em
- André 3000, also known as Dré
- Andre Merritt, also known as Dre, songwriter and member of the Graffiti Artizts
- Dr. Dre, American record producer and rapper
- Mac Dre, deceased American rapper
- Dre & Vidal
- Davidson Road Elementary school, in Winfield, British Columbia, Canada
- Defect Removal Efficiency, a metric used by Quality Control departments of businesses
- Defence Research Establishment, former designation (ca. 1970 until 2000) of each of the Defence Research and Development Canada research centres
- Digital Rectal Examination, in medicine
- DRE voting machine
- Director of Religious Exploration, a title in most congregations of the Unitarian Church
- Disability & Rehabilitation, a medical journal
- Division de la réglementation des explosifs (DRE, Explosives Regulatory Division in English), a division of Natural Resources Canada
- Doctor of Religious Education
- Drug Recognition Expert
- Dry Rock Equivalent, used in volcanology