Cast
- Neil Patrick Harris as Billy/Dr. Horrible: An aspiring supervillain of the mad scientist variety with the catchphrase, "I've got a Ph.D in Horribleness." He desires to become a member of Bad Horse's Evil League of Evil and use his inventions to take over the world and enact social change for the betterment of humanity. His socio-political beliefs include the paradoxical idea of autocratic anarchy: "The world is a mess, and I just... need to rule it." As Billy, he struggles to make a romantic connection with Penny.
- Nathan Fillion as Captain Hammer: Dr. Horrible's archenemy. Hammer is self-centered and possesses super-human strength and near-invulnerability. He enjoys harassing Dr. Horrible even when the situation does not warrant it.
- Felicia Day as Penny: Dr. Horrible's love interest. She is idealistic and generous, and volunteers at a homeless shelter.
- Simon Helberg as Moist: Dr. Horrible's friend and sidekick, who has the underwhelming ability to dampen things. Dr. Horrible calls him "my evil moisture buddy."
Several colleagues of Joss Whedon have cameo roles in the series. Marti Noxon, an executive producer on Buffy the Vampire Slayer, portrays a newsreader alongside Buffy and Angel writer David Fury. Buffy and Angel writers Doug Petrie and Drew Goddard cameo as supervillains Professor Normal and Fake Thomas Jefferson, respectively. Jed, Joss, and Zack Whedon all provide the singing voices of Bad Horse Chorus. Zack also plays the man who rolls the gurney with Penny on it out of frame, and Jed Whedon also appears as the supervillain Dead Bowie, while Maurissa Tancharoen plays a superhero/supervillain groupie as well as the background voice on "Everything You Ever."
Read more about this topic: Dr. Horrible's Sing-Along Blog
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“Sometimes, because of its immediacy, television produces a kind of electronic parable. Berlin, for instance, on the day the Wall was opened. Rostropovich was playing his cello by the Wall that no longer cast a shadow, and a million East Berliners were thronging to the West to shop with an allowance given them by West German banks! At that moment the whole world saw how materialism had lost its awesome historic power and become a shopping list.”
—John Berger (b. 1926)