DPF is an acronym which can mean:
- Days post fertilisation. In biology, this is used to describe the state of development of an embryo of a given species.
- Deadly Physical Force, a legal term determining the type of physical force used in self defense.
- Dense plasma focus, a plasma machine that produces, by electromagnetic acceleration and compression, short-lived plasma that is so hot and dense that it becomes a copious multi-radiation source.
- Defence Police Federation, a British Police union
- Diesel Particulate Filter is a device designed to remove diesel particulate matter or soot from the exhaust gas of a diesel engine.
- Digital photo frame or digital picture frame, a picture frame that displays digital photos using a digital screen without the need for printing.
- Departamento de Polícia Federal (Federal Police Department), the Brazilian federal police (usually shortened to PF).