Dorret Boomsma - Research

Research

Twin studies provide a way to understand how genotype affects an observable characteristic (called a phenotype). In short, identical (monozygotic) twins carry the same alleles for 100% of their genes whereas fraternal (dizygotic) twins will carry different alleles at 50% of the genes for which their parents had different genotypes. So if some characteristic (say, depression) that is observed in one identical twin is always observed in the other one, but this does not hold for fraternal twins, then one can conclude that heredity plays an important role in causing the condition.

Boomsma has been a pioneer in collecting a broad spectrum of data (e.g., medical histories, IQ tests, MRI scans) and biological material (e.g., DNA and RNA samples, blood and urine samples) from thousands of twins and analyzing them to determine the role of genetics in characteristics as varied as adult height, brain volume, intelligence, migraine headaches, anxiety, drug addiction, and love of coffee.

Her results span a wide range of behavioral characteristics, including discovery of the surprisingly large genetic component to feelings of loneliness, the fact that first borns have higher IQs than their younger siblings, and the increased influence of genetics on body weight as children grow older.

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