Mechanics of Docking
To perform a docking screen, the first requirement is a structure of the protein of interest. Usually the structure has been determined using a biophysical technique such as x-ray crystallography, or less often, NMR spectroscopy. This protein structure and a database of potential ligands serve as inputs to a docking program. The success of a docking program depends on two components: the search algorithm and the scoring function.
Read more about this topic: Docking (molecular)
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“It is only the impossible that is possible for God. He has given over the possible to the mechanics of matter and the autonomy of his creatures.”
—Simone Weil (1909–1943)