DNA replication factor Cdt1 is a protein that in humans is encoded by the CDT1 gene.
The protein encoded by this gene is a key licensing factor which, along with the protein Cdc6, functions to license DNA by forming the pre-replication complex (pre-RC). Its activity during the cell cycle is tightly regulated by its association with the protein geminin, which both inhibits Cdt1 activity during S phase in order to prevent re-replication of DNA and prevents it from ubiquitination and subsequent proteolysis.
Read more about DNA Replication Factor CDT1: Orthologs, Interactions
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