Reverse Transcriptase
Some viruses also encode special DNA polymerases, such as Hepatitis B virus DNA polymerase. These may selectively replicate viral DNA through a variety of mechanisms. Retroviruses encode an unusual DNA polymerase called reverse transcriptase, which is an RNA-dependent DNA polymerase (RdDp). It polymerizes DNA from a template of RNA. The reverse transcriptase family contains examples from both retroviruses and eukaryotic polymerases. The eukaryotic polymerases are usually restricted to telomerases. These polymerases use an RNA template to synthesize the DNA strand.
DNA polymerase family A |
|
c:o6-methyl-guanine pair in the polymerase-2 basepair position |
Identifiers |
Symbol |
DNA_pol_A |
Pfam |
PF00476 |
InterPro |
IPR001098 |
PROSITE |
PDOC00412 |
SCOP |
1dpi |
SUPERFAMILY |
1dpi |
Available protein structures: |
Pfam |
structures |
PDB |
RCSB PDB; PDBe |
PDBsum |
structure summary |
|
DNA polymerase family B |
|
crystal structure of rb69 gp43 in complex with dna containing thymine glycol |
Identifiers |
Symbol |
DNA_pol_B |
Pfam |
PF00136 |
Pfam clan |
CL0194 |
InterPro |
IPR006134 |
PROSITE |
PDOC00107 |
SCOP |
1noy |
SUPERFAMILY |
1noy |
Available protein structures: |
Pfam |
structures |
PDB |
RCSB PDB; PDBe |
PDBsum |
structure summary |
|
DNA polymerase type B, organellar and viral |
|
phi29 dna polymerase, orthorhombic crystal form, ssdna complex |
Identifiers |
Symbol |
DNA_pol_B_2 |
Pfam |
PF03175 |
Pfam clan |
CL0194 |
InterPro |
IPR004868 |
Available protein structures: |
Pfam |
structures |
PDB |
RCSB PDB; PDBe |
PDBsum |
structure summary |
|