DNA Polymerase - Variation Across Species - Eukaryotic DNA Polymerase - Reverse Transcriptase

Reverse Transcriptase

Some viruses also encode special DNA polymerases, such as Hepatitis B virus DNA polymerase. These may selectively replicate viral DNA through a variety of mechanisms. Retroviruses encode an unusual DNA polymerase called reverse transcriptase, which is an RNA-dependent DNA polymerase (RdDp). It polymerizes DNA from a template of RNA. The reverse transcriptase family contains examples from both retroviruses and eukaryotic polymerases. The eukaryotic polymerases are usually restricted to telomerases. These polymerases use an RNA template to synthesize the DNA strand.


DNA polymerase family A
c:o6-methyl-guanine pair in the polymerase-2 basepair position
Identifiers
Symbol DNA_pol_A
Pfam PF00476
InterPro IPR001098
PROSITE PDOC00412
SCOP 1dpi
SUPERFAMILY 1dpi
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
DNA polymerase family B
crystal structure of rb69 gp43 in complex with dna containing thymine glycol
Identifiers
Symbol DNA_pol_B
Pfam PF00136
Pfam clan CL0194
InterPro IPR006134
PROSITE PDOC00107
SCOP 1noy
SUPERFAMILY 1noy
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
DNA polymerase type B, organellar and viral
phi29 dna polymerase, orthorhombic crystal form, ssdna complex
Identifiers
Symbol DNA_pol_B_2
Pfam PF03175
Pfam clan CL0194
InterPro IPR004868
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary

Read more about this topic:  DNA Polymerase, Variation Across Species, Eukaryotic DNA Polymerase

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