Design
DNA nanostructures must be rationally designed so that the individual nucleic acid strands will assemble into the desired structures. This process usually begins with the specification of a desired target structure or functionality. Then, the overall secondary structure of the target complex is determined, specifying the arrangement of nucleic acid strands within the structure, and which portions of those strands should be bound to each other. The last step is the primary structure design, which is the specification of the actual base sequences of each nucleic acid strand.
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“What but design of darkness to appall?—
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