Mechanism
Uracil-DNA glycosylases are DNA repair enzymes that excise uracil residues from DNA by cleaving the N-glycosylic bond, initiating the base excision repair pathway. Uracil in DNA can arise either through the deamination of cytosine to form mutagenic U:G mispairs, or through the incorporation of dUMP by DNA polymerase to form U:A pairs. These aberrant uracil residues are genotoxic.
Read more about this topic: DNA Glycosylase
Famous quotes containing the word mechanism:
“Ive never known a Philadelphian who wasnt a downright character; possibly a defense mechanism resulting from the dullness of their native habitat.”
—Anita Loos (18881981)
“Life is an offensive, directed against the repetitious mechanism of the Universe.”
—Alfred North Whitehead (18611947)
“A mechanism of some kind stands between us and almost every act of our lives.”
—Sarah Patton Boyle, U.S. civil rights activist and author. The Desegregated Heart, part 3, ch. 2 (1962)