DNA Demethylation - Examples DNA Demethylation

Examples DNA Demethylation

All the cases of DNA demethylation can be divided as global (genome wide) or locus-specific (when just specific sequences are demethylated). The genome wide DNA demethylation occurs:

  1. In mammals:
    1. In the male pronucleus of zygote immediately after fertilization;
    2. In mouse primordial germ cells (PGCs) between E8.5-11.5 day old embryos;
  2. Possibly in amphibia - during midblastula transition.

Examples of specific DNA demethylation:

  1. Genomic imprinting during plant reproduction;
  2. Electroconvulsive stimulation-induced demethylation of neurotrophic factor genes in dentate gyrus neurons in the mouse brain.

Read more about this topic:  DNA Demethylation

Famous quotes containing the words examples and/or dna:

    “It is hardly to be believed how spiritual reflections when mixed with a little physics can hold people’s attention and give them a livelier idea of God than do the often ill-applied examples of his wrath.”
    —G.C. (Georg Christoph)

    “Here [in London, history] ... seemed the very fabric of things, as if the city were a single growth of stone and brick, uncounted strata of message and meaning, age upon age, generated over the centuries to the dictates of some now all-but-unreadable DNA of commerce and empire.”
    —William Gibson (b. 1948)