DNA Demethylation - Examples DNA Demethylation

Examples DNA Demethylation

All the cases of DNA demethylation can be divided as global (genome wide) or locus-specific (when just specific sequences are demethylated). The genome wide DNA demethylation occurs:

  1. In mammals:
    1. In the male pronucleus of zygote immediately after fertilization;
    2. In mouse primordial germ cells (PGCs) between E8.5-11.5 day old embryos;
  2. Possibly in amphibia - during midblastula transition.

Examples of specific DNA demethylation:

  1. Genomic imprinting during plant reproduction;
  2. Electroconvulsive stimulation-induced demethylation of neurotrophic factor genes in dentate gyrus neurons in the mouse brain.

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