Examples
Chemicals which form DNA adducts include:
- acetaldehyde, is a significant constituent of tobacco smoke
- cisplatin binds to DNA and causes crosslinking, leading to death of the cell
- DMBA (7,12-dimethylbenz(a)anthracene)
- malondialdehyde, a naturally occurring product of lipid peroxidation
DNA adducts include:
- etheno-DNA adducts: 1,N(6)-etheno-2'-deoxyadenosine (epsilondA) and 3,N(4)-etheno-2'-deoxycytidine (epsilondC)
By-products include:
- M1G, a by-product of base excision repair (BER) of a specific type of DNA adduct called M1dG.
Read more about this topic: DNA Adduct
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