DNA Adduct - Examples

Examples

Chemicals which form DNA adducts include:

  • acetaldehyde, is a significant constituent of tobacco smoke
  • cisplatin binds to DNA and causes crosslinking, leading to death of the cell
  • DMBA (7,12-dimethylbenz(a)anthracene)
  • malondialdehyde, a naturally occurring product of lipid peroxidation

DNA adducts include:

  • etheno-DNA adducts: 1,N(6)-etheno-2'-deoxyadenosine (epsilondA) and 3,N(4)-etheno-2'-deoxycytidine (epsilondC)

By-products include:

  • M1G, a by-product of base excision repair (BER) of a specific type of DNA adduct called M1dG.

Read more about this topic:  DNA Adduct

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